KEGG   Homo sapiens (human): 7075
Entry
7075              CDS       T01001                                 
Symbol
TIE1, JTK14, LMPHM11, TIE
Name
(RefSeq) tyrosine kinase with immunoglobulin like and EGF like domains 1
  KO
K05120  tyrosine kinase receptor 1 [EC:2.7.10.1]
Organism
hsa  Homo sapiens (human)
Disease
H00535  Lymphatic malformation
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases [BR:hsa01001]
    7075 (TIE1)
Enzymes [BR:hsa01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.10  Protein-tyrosine kinases
    2.7.10.1  receptor protein-tyrosine kinase
     7075 (TIE1)
Protein kinases [BR:hsa01001]
 Receptor tyrosine kinases (RTK)
  TIE family
   7075 (TIE1)
SSDB
Motif
Pfam: PK_Tyr_Ser-Thr Pkinase fn3 ig Pur_ac_phosph_N I-set Ig_3 EGF_2 hEGF Ig_2 C2-set Pkinase_fungal Laminin_EGF Haspin_kinase DUF4702
Other DBs
NCBI-GeneID: 7075
NCBI-ProteinID: NP_005415
OMIM: 600222
HGNC: 11809
Ensembl: ENSG00000066056
UniProt: P35590
Structure
Position
1:43300982..43323108
AA seq 1138 aa
MVWRVPPFLLPILFLASHVGAAVDLTLLANLRLTDPQRFFLTCVSGEAGAGRGSDAWGPP
LLLEKDDRIVRTPPGPPLRLARNGSHQVTLRGFSKPSDLVGVFSCVGGAGARRTRVIYVH
NSPGAHLLPDKVTHTVNKGDTAVLSARVHKEKQTDVIWKSNGSYFYTLDWHEAQDGRFLL
QLPNVQPPSSGIYSATYLEASPLGSAFFRLIVRGCGAGRWGPGCTKECPGCLHGGVCHDH
DGECVCPPGFTGTRCEQACREGRFGQSCQEQCPGISGCRGLTFCLPDPYGCSCGSGWRGS
QCQEACAPGHFGADCRLQCQCQNGGTCDRFSGCVCPSGWHGVHCEKSDRIPQILNMASEL
EFNLETMPRINCAAAGNPFPVRGSIELRKPDGTVLLSTKAIVEPEKTTAEFEVPRLVLAD
SGFWECRVSTSGGQDSRRFKVNVKVPPVPLAAPRLLTKQSRQLVVSPLVSFSGDGPISTV
RLHYRPQDSTMDWSTIVVDPSENVTLMNLRPKTGYSVRVQLSRPGEGGEGAWGPPTLMTT
DCPEPLLQPWLEGWHVEGTDRLRVSWSLPLVPGPLVGDGFLLRLWDGTRGQERRENVSSP
QARTALLTGLTPGTHYQLDVQLYHCTLLGPASPPAHVLLPPSGPPAPRHLHAQALSDSEI
QLTWKHPEALPGPISKYVVEVQVAGGAGDPLWIDVDRPEETSTIIRGLNASTRYLFRMRA
SIQGLGDWSNTVEESTLGNGLQAEGPVQESRAAEEGLDQQLILAVVGSVSATCLTILAAL
LTLVCIRRSCLHRRRTFTYQSGSGEETILQFSSGTLTLTRRPKLQPEPLSYPVLEWEDIT
FEDLIGEGNFGQVIRAMIKKDGLKMNAAIKMLKEYASENDHRDFAGELEVLCKLGHHPNI
INLLGACKNRGYLYIAIEYAPYGNLLDFLRKSRVLETDPAFAREHGTASTLSSRQLLRFA
SDAANGMQYLSEKQFIHRDLAARNVLVGENLASKIADFGLSRGEEVYVKKTMGRLPVRWM
AIESLNYSVYTTKSDVWSFGVLLWEIVSLGGTPYCGMTCAELYEKLPQGYRMEQPRNCDD
EVYELMRQCWRDRPYERPPFAQIALQLGRMLEARKAYVNMSLFENFTYAGIDATAEEA
NT seq 3417 nt   +upstreamnt  +downstreamnt
atggtctggcgggtgccccctttcttgctccccatcctcttcttggcttctcatgtgggc
gcggcggtggacctgacgctgctggccaacctgcggctcacggacccccagcgcttcttc
ctgacttgcgtgtctggggaggccggggcggggaggggctcggacgcctggggcccgccc
ctgctgctggagaaggacgaccgtatcgtgcgcaccccgcccgggccacccctgcgcctg
gcgcgcaacggttcgcaccaggtcacgcttcgcggcttctccaagccctcggacctcgtg
ggcgtcttctcctgcgtgggcggtgctggggcgcggcgcacgcgcgtcatctacgtgcac
aacagccctggagcccacctgcttccagacaaggtcacacacactgtgaacaaaggtgac
accgctgtactttctgcacgtgtgcacaaggagaagcagacagacgtgatctggaagagc
aacggatcctacttctacaccctggactggcatgaagcccaggatgggcggttcctgctg
cagctcccaaatgtgcagccaccatcgagcggcatctacagtgccacttacctggaagcc
agccccctgggcagcgccttctttcggctcatcgtgcggggttgtggggctgggcgctgg
gggccaggctgtaccaaggagtgcccaggttgcctacatggaggtgtctgccacgaccat
gacggcgaatgtgtatgcccccctggcttcactggcacccgctgtgaacaggcctgcaga
gagggccgttttgggcagagctgccaggagcagtgcccaggcatatcaggctgccggggc
ctcaccttctgcctcccagacccctatggctgctcttgtggatctggctggagaggaagc
cagtgccaagaagcttgtgcccctggtcattttggggctgattgccgactccagtgccag
tgtcagaatggtggcacttgtgaccggttcagtggttgtgtctgcccctctgggtggcat
ggagtgcactgtgagaagtcagaccggatcccccagatcctcaacatggcctcagaactg
gagttcaacttagagacgatgccccggatcaactgtgcagctgcagggaaccccttcccc
gtgcggggcagcatagagctacgcaagccagacggcactgtgctcctgtccaccaaggcc
attgtggagccagagaagaccacagctgagttcgaggtgccccgcttggttcttgcggac
agtgggttctgggagtgccgtgtgtccacatctggcggccaagacagccggcgcttcaag
gtcaatgtgaaagtgccccccgtgcccctggctgcacctcggctcctgaccaagcagagc
cgccagcttgtggtctccccgctggtctcgttctctggggatggacccatctccactgtc
cgcctgcactaccggccccaggacagtaccatggactggtcgaccattgtggtggacccc
agtgagaacgtgacgttaatgaacctgaggccaaagacaggatacagtgttcgtgtgcag
ctgagccggccaggggaaggaggagagggggcctgggggcctcccaccctcatgaccaca
gactgtcctgagcctttgttgcagccgtggttggagggctggcatgtggaaggcactgac
cggctgcgagtgagctggtccttgcccttggtgcccgggccactggtgggcgacggtttc
ctgctgcgcctgtgggacgggacacgggggcaggagcggcgggagaacgtctcatccccc
caggcccgcactgccctcctgacgggactcacgcctggcacccactaccagctggatgtg
cagctctaccactgcaccctcctgggcccggcctcgccccctgcacacgtgcttctgccc
cccagtgggcctccagccccccgacacctccacgcccaggccctctcagactccgagatc
cagctgacatggaagcacccggaggctctgcctgggccaatatccaagtacgttgtggag
gtgcaggtggctgggggtgcaggagacccactgtggatagacgtggacaggcctgaggag
acaagcaccatcatccgtggcctcaacgccagcacgcgctacctcttccgcatgcgggcc
agcattcaggggctcggggactggagcaacacagtagaagagtccaccctgggcaacggg
ctgcaggctgagggcccagtccaagagagccgggcagctgaagagggcctggatcagcag
ctgatcctggcggtggtgggctccgtgtctgccacctgcctcaccatcctggctgccctt
ttaaccctggtgtgcatccgcagaagctgcctgcatcggagacgcaccttcacctaccag
tcaggctcgggcgaggagaccatcctgcagttcagctcagggaccttgacacttacccgg
cggccaaaactgcagcccgagcccctgagctacccagtgctagagtgggaggacatcacc
tttgaggacctcatcggggaggggaacttcggccaggtcatccgggccatgatcaagaag
gacgggctgaagatgaacgcagccatcaaaatgctgaaagagtatgcctctgaaaatgac
catcgtgactttgcgggagaactggaagttctgtgcaaattggggcatcaccccaacatc
atcaacctcctgggggcctgtaagaaccgaggttacttgtatatcgctattgaatatgcc
ccctacgggaacctgctagattttctgcggaaaagccgggtcctagagactgacccagct
tttgctcgagagcatgggacagcctctacccttagctcccggcagctgctgcgtttcgcc
agtgatgcggccaatggcatgcagtacctgagtgagaagcagttcatccacagggacctg
gctgcccggaatgtgctggtcggagagaacctagcctccaagattgcagacttcggcctt
tctcggggagaggaggtttatgtgaagaagacgatggggcgtctccctgtgcgctggatg
gccattgagtccctgaactacagtgtctataccaccaagagtgatgtctggtcctttgga
gtccttctttgggagatagtgagccttggaggtacaccctactgtggcatgacctgtgcc
gagctctatgaaaagctgccccagggctaccgcatggagcagcctcgaaactgtgacgat
gaagtgtacgagctgatgcgtcagtgctggcgggaccgtccctatgagcgaccccccttt
gcccagattgcgctacagctaggccgcatgctggaagccaggaaggcctatgtgaacatg
tcgctgtttgagaacttcacttacgcgggcattgatgccacagctgaggaggcctga

  All links  
Ontology (3)   
   KEGG BRITE (3)   
Disease (3)   
   KEGG DISEASE (1)   
   OMIM (2)   
Chemical reaction (1)   
   KEGG ENZYME (1)   
Genome (1)   
   KEGG GENOME (1)   
Gene (29)   
   KEGG ORTHOLOGY (1)   
   RefGene (22)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   HGNC (1)   
   Ensembl (1)   
   RIKEN BRC-DNA (1)   
   OC (1)   
Protein sequence (12)   
   UniProt (1)   
   SWISS-PROT (1)   
   RefSeq(pep) (10)   
DNA sequence (44)   
   RefSeq(nuc) (10)   
   GenBank (17)   
   EMBL (17)   
3D Structure (1)   
   PDB (1)   
Protein domain (15)   
   Pfam (15)   
All databases (109)   

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